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How does Hydrocodone/Acetaminophen (Norco) work?

A combination of two painkillers called Norco (hydrocodone and acetaminophen) is used to treat moderate to severe pain. An opioid called hydrocodone blocks the transmission of pain signals to the brain and spinal cord. ( Buy Hydrocodone Online ) Acetaminophen, also marketed under the brand name Tylenol, is a non-opioid that reduces pain by preventing the release of specific molecules in the brain.


Information on dosage (Common Adult Dose for Chronic Pain):

The following dose recommendations should only be viewed as suggestions for what should actually be managed as a series of clinical decisions over time.


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For patients who are not opioid-tolerant and as the first opioid analgesic:

Zohydro(R) ER Extended-Release Capsules: 10 mg orally every 12 hours for the first dose.

Tablets with an extended-release (Hysingla(R) ER): Initially, use 20 mg once every 24 hours by mouth.


Observe patients attentively for respiratory depression, especially during the first 24 to 72 hours, as using greater initial dosages in individuals who are not opioid-tolerant may result in deadly respiratory depression.

A patient who has been receiving one of the following opioids for at least one week is considered to be opioid-tolerant: oral morphine 60 mg/day, fentanyl transdermal patch 25 mcg/hour, oral oxycodone 30 mg/day, oral hydromorphone 8 mg/day, oral oxymorphone 25 mg/day, or an equivalent dose of another opioid.


Before using this medication

If you have any of the following conditions, you shouldn’t use hydrocodone:

severe respiratory difficulties or asthma; or

an obstruction in your intestines or stomach.

Tell your doctor about any of the following to ensure that hydrocodone is safe for you:

issues with breathing and sleep apnea;

a brain tumor, a head injury, or seizures;

addiction to drugs or alcohol, or mental disease;

urinary incontinence

kidney or liver disease

issues with your thyroid, pancreas, or gallbladder; or

a condition of the cardiac rhythm known as long QT syndrome.


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Your unborn child may develop a drug dependence if you take opioid medications while you are pregnant. After birth, the newborn may have withdrawal symptoms that are potentially fatal. Babies who are born opioid-dependent may require several weeks of medical care.

Before taking hydrocodone while nursing, consult a doctor, if you observe the nursing infant being sleepy or breathing slowly, let your doctor know.


Hydrocodone/Acetaminophen (325mg) Warnings/Precautions:

respiratory depression that is life-threatening; monitor within the first 24 to 72 hours of starting medication and after dose increases. Overdose deaths could result from accidental exposure (esp. in children). Consider non-opioid analgesics if you have COPD, cor pulmonale, a lowered respiratory reserve, hypoxia, hypercapnia, or a history of respiratory depression. Possibility of abuse (monitor). Acetaminophen doses >4g/day, concurrent alcohol use, underlying liver disease, or use of more than one acetaminophen-containing medicine all increase the risk of hepatotoxicity.

 adrenal underdevelopment head trauma. Monitor for elevated intracranial pressure and brain malignancies. epilepsy diseases. brain depression Avoid shock, impaired consciousness, and coma. stomach pain that is recent. illness of the bile ducts. Pancreatitis acute. drug addict’s impairment of the liver or kidneys; observe. Regularly reevaluate. Avoid stopping abruptly. Elderly. Cachectic. Debilitated. Potential newborn opioid withdrawal syndrome following extended use during pregnancy (Cat. C). I am not advised: about childbirth, or breastfeeding mothers.


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Mind User Asked on June 28, 2022 in Health.
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